PUBLICATION
Gdf11 regulates left-right asymmetry development through TGF-β signal
- Authors
- Yao, W., Wei, Z., Tian, X., Tan, J., Liu, J.
- ID
- ZDB-PUB-241016-12
- Date
- 2024
- Source
- Cell Proliferation : e13765e13765 (Journal)
- Registered Authors
- Liu, Jingwen
- Keywords
- none
- MeSH Terms
-
- Transforming Growth Factor beta*/metabolism
- Animals
- Signal Transduction*
- Zebrafish*/embryology
- Zebrafish*/metabolism
- Zebrafish Proteins*/genetics
- Zebrafish Proteins*/metabolism
- Smad2 Protein/metabolism
- Gene Expression Regulation, Developmental
- Forkhead Transcription Factors/genetics
- Forkhead Transcription Factors/metabolism
- Growth Differentiation Factors*/genetics
- Growth Differentiation Factors*/metabolism
- Bone Morphogenetic Proteins/metabolism
- Body Patterning*/genetics
- PubMed
- 39407407 Full text @ Cell Prolif.
Citation
Yao, W., Wei, Z., Tian, X., Tan, J., Liu, J. (2024) Gdf11 regulates left-right asymmetry development through TGF-β signal. Cell Proliferation. :e13765e13765.
Abstract
During the embryonic developmental stage in vertebrates, internal organs are arranged along the left-right axis. Disruptions in this process can result in congenital diseases or laterality disorders. The molecular mechanisms of left-right asymmetry in vertebrate development remain largely unclear. Due to its straightforward structure, zebrafish has become a favoured model for studying early laterality events. Here, we demonstrate that growth and development factor 11 (Gdf11) is essential for left-right development via TGF-β signalling. Morphological analysis showed that gdf11 morphants and mutants displayed clear heart and liver laterality disorders in a Nodal signal-dependent manner. Additionally, we found that Kupffer's vesicle formation and ciliogenesis were impaired following gdf11 deletion. We also observed that Gdf11 may form a heterodimer with Spaw, which promotes Smad2/3 phosphorylation and activates TGF-β signalling. Subsequently, Gdf11 promotes left-right laterality by stimulating Foxj1a and its target gene expression. In summary, we reveal a critical role of Gdf11 in left-right patterning, providing fundamental insights into the developmental process of left-right asymmetry.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping