PUBLICATION
Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish
- Authors
- Schauerte, H.E., van Eeden, F.J.M., Fricke, C., Odenthal, J., Strähle, U., Haffter, P.
- ID
- ZDB-PUB-980729-15
- Date
- 1998
- Source
- Development (Cambridge, England) 125: 2983-2993 (Journal)
- Registered Authors
- Fricke, Cornelia, Haffter, Pascal, Odenthal, Joerg, Schauerte, Heike, Strähle, Uwe, van Eeden, Freek
- Keywords
- sonic hedgehog; sonic-you; zebrafish; floor plate; somitogenesis
- MeSH Terms
-
- Transcription Factors/biosynthesis
- Cyclic AMP-Dependent Protein Kinases/metabolism
- Paired Box Transcription Factors
- Repressor Proteins
- Nervous System Malformations
- Zebrafish Proteins
- Sequence Analysis, DNA
- Hedgehog Proteins
- Muscles/cytology
- Genetic Complementation Test
- Protein Sorting Signals/genetics
- Somites*
- PAX2 Transcription Factor
- Retinal Ganglion Cells
- Trans-Activators*
- Eye Proteins
- Mutation
- Axons
- Proteins/metabolism*
- RNA Splicing
- Body Patterning
- Embryonic Induction*
- Signal Transduction
- Nervous System/embryology*
- DNA-Binding Proteins/biosynthesis
- Stem Cells
- Eye/embryology
- Animals
- Homeodomain Proteins/biosynthesis
- Zebrafish/embryology*
- PubMed
- 9655820 Full text @ Development
Citation
Schauerte, H.E., van Eeden, F.J.M., Fricke, C., Odenthal, J., Strähle, U., Haffter, P. (1998) Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish. Development (Cambridge, England). 125:2983-2993.
Abstract
Sonic hedgehog (Shh) is a secreted protein that is involved in the organization and patterning of several tissues in vertebrates. We show that the zebrafish sonic-you (syu) gene, a member of a group of five genes required for somite patterning, is encoding Shh. Embryos mutant for a deletion of syu display defects in patterning of the somites, the lateral floor plate cells, the pectoral fins, the axons of motorneurons and the retinal ganglion cells. In contrast to mouse embryos lacking Shh activity, syu mutant embryos do form medial floor plate cells and motorneurons. Since ectopic overexpression of shh in zebrafish embryos does not induce ectopic medial floor plate cells, we conclude that shh is neither required nor sufficient to induce this cell type in the zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping