PUBLICATION
Analysis of zebrafish semaphorin reveals potential functions in vivo
- Authors
- Halloran, M.C., Severance, S.M., Yee, C.S., Gemza, D.L., Raper, J.A., and Kuwada, J.Y.
- ID
- ZDB-PUB-990119-21
- Date
- 1999
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 214: 13-25 (Journal)
- Registered Authors
- Halloran, Mary, Kuwada, John
- Keywords
- axon guidance; semaphorin; collapsin; zebrafish
- MeSH Terms
-
- Rhombencephalon/embryology
- Gene Expression Regulation, Developmental
- Animals
- Axons/physiology
- Mutation
- Chickens
- Molecular Sequence Data
- Spinal Cord/embryology
- Notochord/embryology
- Prosencephalon/embryology
- Sequence Homology, Amino Acid
- RNA, Messenger
- Zebrafish/embryology
- Zebrafish/genetics
- Zebrafish/physiology
- Nerve Tissue Proteins/genetics
- Nerve Tissue Proteins/physiology*
- Semaphorins
- Amino Acid Sequence
- Central Nervous System/embryology
- Nerve Growth Factors/genetics
- Nerve Growth Factors/physiology*
- Neural Crest/embryology
- Branchial Region/embryology
- Zebrafish Proteins*
- Mesencephalon/embryology
- PubMed
- 9915572 Full text @ Dev. Dyn.
Citation
Halloran, M.C., Severance, S.M., Yee, C.S., Gemza, D.L., Raper, J.A., and Kuwada, J.Y. (1999) Analysis of zebrafish semaphorin reveals potential functions in vivo. Developmental Dynamics : an official publication of the American Association of Anatomists. 214:13-25.
Abstract
The semaphorin/collapsin gene family is a large and diverse family encoding both secreted and transmembrane proteins, some of which are thought to act as repulsive axon guidance molecules. However, the function of most semaphorins is still unknown. We have cloned and characterized several semaphorins in the zebrafish in order to assess their in vivo function. Zebrafish semaZ2 is expressed in a dynamic and restricted pattern during the period of axon outgrowth that indicates potential roles in the guidance of several axon pathways. Analysis of mutant zebrafish with reduced semaZ2 expression reveals axon pathfinding errors that implicate SemaZ2 in normal guidance.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping