| ZFIN ID: ZDB-EXP-230222-12 |
Experiment Conditions Description: heat shock, chemical treatment by environment: fingolimod
| heat shock |
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| Name: | heat shock |
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| Synonyms: | |
| Definition: | Temperature shock condition in which fish are subjected for a short period of time to temperature higher than the controlled temperature. The standard controlled temperature (according to the zebrafish book) is 28.5 degrees C. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000166] |
| chemical treatment by environment: fingolimod |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | fingolimod |
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| Synonyms: | 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol, fingolimod, fingolimodum, FTY720 |
| Definition: | An aminodiol that consists of propane-1,3-diol having amino and 2-(4-octylphenyl)ethyl substituents at the 2-position. It is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis. A prodrug, fingolimod is phosphorylated by sphingosine kinase to active metabolite fingolimod-phosphate, a structural analogue of sphingosine 1-phosphate. |
| Ontology: | ChEBI [CHEBI:63115] ( EBI ) |
| Publication: | Xu et al., 2019 |
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