| ZFIN ID: ZDB-EXP-260611-8 |
Experiment Conditions Description: chemical treatment by injection: lipopolysaccharide, chemical treatment by environment: prednisone, primary cell culture: retina
| chemical treatment by injection: lipopolysaccharide |
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| Name: | chemical treatment by injection |
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| Synonyms: | |
| Definition: | Chemical treatment in which the chemical is injected into the zebrafish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000237] |
| Name: | lipopolysaccharide |
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| Synonyms: | Lipopolysaccharide, lipopolysaccharides, LPS |
| Definition: | Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). |
| Ontology: | ChEBI [CHEBI:16412] ( EBI ) |
| chemical treatment by environment: prednisone |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | prednisone |
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| Synonyms: | 1,2-Dehydrocortisone, 1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione, 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione, Dehydrocortisone, prednison, prednisona, prednisone, prednisonum |
| Definition: | A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a β-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid. |
| Ontology: | ChEBI [CHEBI:8382] ( EBI ) |
| primary cell culture: retina |
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| Name: | primary cell culture |
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| Synonyms: | |
| Definition: | In vitro culture condition in which an embryo or adult fish is dissociated to a single cell suspension. The analysis is made on this cell culture. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000145] |
| Name: | retina |
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| Synonyms: | retinas |
| Definition: | Multi-tissue structure that contains the retinal neural layer and the retinal pigmented epithelium, and develops from the optic cup. |
| Ontology: | Anatomy Ontology [ZFA:0000152] |
| Publication: | Xiao et al., 2022 |
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