Term Name: motixafortide
Synonyms: (3S,6S,9S,12R,17R,20S,23S,26S,29R,34aS)-26,29-bis(4-aminobutyl)-N-[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]-17-{[(2S)-2-{[(2S)-5-carbamimidamido-2-{[(2S)-5-carbamimidamido-2-(4-fluorobenzamido)pentanoyl]amino}pentanoyl]amino}-3-(naphthalen-2-yl)pr, 4F-benzoyl-TN14003, BKT 140, BKT-140, BKT140, BL 8040, BL-8040, BL8040, motixafortida, motixafortide, motixafortidum, TF 14016, TF-14016, TF14016, TN-14003
Definition: A heterodetic cyclic peptide that has antineoplastic activity. It is a CXC chemokine receptor 4 (CXCR4) antagonist with an IC50 value of 0.8 nM and is currently under clinical investigation for the treatment of hematological malignancies, solid tumors, and stem cell mobilization. It was granted orphan drug designation by the FDA for the treatment of pancreatic cancer in 2019.
Ontology: ChEBI [CHEBI:145536]  ( EBI )

Relationships
is a type of: heterodetic cyclic peptide
has_role: antineoplastic agent apoptosis inducer C-X-C chemokine receptor type 4 antagonist
inverse has_part: motixafortide acetate