Term Name: calotropone
Synonyms: (3beta,12beta,14beta,17alpha)-3,14,17-trihydroxy-20-oxopregn-5-en-12-yl benzoate, 12beta-benzoyloxy-3beta,14beta,17beta-trihydroxypregnane-20-one, 12beta-O-benzoyl-3beta,14beta,17beta-trihydroxypregnane-20-one, 3beta,14beta,17-trihydroxy-20-oxo-17alpha-pregn-5-en-12beta-yl benzoate
Definition: A 20-oxo steroid that is 17alpha-pregn-5-en-20-one substituted by a benzoyloxy group at position 12 and hydroxy groups at positions 3, 14 and 17 (the 3beta,12beta,14beta stereoisomer). It is isolated from the roots of Calotropis gigantea and displays inhibitory effects towards chronic myelogenous leukemia K562 and human gastric cancer SGC-7901 cell lines.
Ontology: ChEBI [CHEBI:65568]  ( EBI )

Relationships
is a type of: 3beta-hydroxy-Delta(5)-steroid 14beta-hydroxy steroid 17beta-hydroxy steroid 20-oxo steroid benzoate ester tertiary alpha-hydroxy ketone
has_parent_hydride: pregnane
has_role: antineoplastic agent metabolite