Term Name: GSK461364
Synonyms: 5-[6-[(4-methyl-1-piperazinyl)methyl]-1-benzimidazolyl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide, 5-{6-[(4-methylpiperazin-1-yl)methyl]-1H-benzimidazol-1-yl}-3-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide, GSK 461364, GSK 461364A, GSK-461364, GSK-461364A, GSK461364A
Definition: A member of the class of benzimidazoles that is 1H-benzimidazole substituted by 5-carbamoyl-4-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophen-2-yl and (4-methylpiperazin-1-yl)methyl groups at positions 1 and 6, respectively. It is an ATP-competitive polo-like kinase 1 (PLK1) inhibitor (Ki = 2.2 nM).
Ontology: ChEBI [CHEBI:91333]  ( EBI )

Relationships
is a type of: (trifluoromethyl)benzenes benzimidazoles ether N-methylpiperazine primary carboxamide thiophenes
has_role: antineoplastic agent apoptosis inducer EC 2.7.11.21 (polo kinase) inhibitor