Term Name: momelotinib
Synonyms: CYT 11387, CYT 387, CYT-11387, CYT-387, CYT387, GS-0387, LM-1149, momelotinib, momelotinibum, N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide, N-(cyanomethyl)-4-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)benzamide, N-(cyanomethyl)-4-(2-((4-morpholinophenyl)-amino)pyrimidin-4-yl)benzamide, N-(cyanomethyl)-4-[2-[4-(4-morpholinyl)anilino]-4-pyrimidinyl]benzamide, N-(cyanomethyl)-4-{2-[4-(morpholin-4-yl)anilino]pyrimidin-4-yl}benzamide, Ojjaara
Definition: A benzamide obtained by formal condensation of the carboxy group of 4-{2-[4-(morpholin-4-yl)anilino]pyrimidin-4-yl}benzoic acid with the primary amino group of aminoacetonitrile. It is an ATP-competitive JAK1/JAK2 inhibitor with IC50 of 11 nM and 18 nM, respectively. Used for the treatment of patients with intermediate- or high-risk myelofibrosis.
Ontology: ChEBI [CHEBI:91407]  ( EBI )

Relationships
is a type of: aminopyrimidine benzamides morpholines nitrile secondary amino compound tertiary amino compound
has_role: anti-anaemic agent antineoplastic agent apoptosis inducer EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor