Term Name: GSK-J4
Synonyms: 3-[[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-4-pyrimidinyl]amino]propanoic acid ethyl ester, ethyl 3-((2-(pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoate, ethyl N-[2-(pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)pyrimidin-4-yl]-beta-alaninate, GSK J4, GSKJ4
Definition: A member of the class of aminopyrimidines that is pyrimidine substituted by pyridin-2-yl, 3-ethoxy-3-oxopropylamino, and 1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl groups at positions 2, 4, and 6, respectively. It is an inhibitor of the histone demethylase JMJD3/UTX.
Ontology: ChEBI [CHEBI:95077]  ( EBI )

Relationships
is a type of: aminopyrimidine benzazepine ethyl ester pyridines secondary amino compound tertiary amino compound
has_functional_parent: GSK-J1
has_role: antineoplastic agent EC 1.14.11.68 ([histone H3]-trimethyl-L-lysine(27) demethylase) inhibitor ferroptosis inducer prodrug