Term Name:	Gordon Holmes syndrome
Synonyms:	CAHH, cerebellar ataxia-hypogonadism syndrome, GDHS, LHRH deficiency and ataxia, luteinizing hormone-releasing hormone deficiency with ataxia
Definition:	An inherited metabolic disorder characterized by progressive cognitive decline, dementia, hypogonadotropic hypogonadism, and variable movement disorders resulting from disordered ubiquitination that has_material_basis_in homozygous or compound heterozygous mutation in the RNF216 gene on chromosome 7p22.1.
Ontology:	Human Disease [DOID:0111587]   ( DOID:0111587 )