Term Name:	methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
Synonyms:	methylmalonate-semialdehyde dehydrogenase (acylating) activity, MMSA dehydrogenase activity, MSDH activity
Definition:	Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + hydrogencarbonate + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product.
Ontology:	GO: Molecular Function [GO:0004491]    QuickGO    AmiGO