| Synonyms: |
delta(6)-acyl CoA desaturase activity,
delta(6)-desaturase activity,
delta(6)-fatty acyl-CoA desaturase activity,
delta6-acyl CoA desaturase activity,
delta6-desaturase activity,
delta6-fatty acyl-CoA desaturase activity,
fatty acid 6-desaturase activity,
fatty acid delta(6)-desaturase activity,
fatty acid delta6-desaturase activity,
linoleate desaturase activity,
linoleic acid desaturase activity,
linoleic desaturase activity,
linoleoyl CoA desaturase activity,
linoleoyl-CoA desaturase activity,
linoleoyl-coenzyme A desaturase activity,
long-chain fatty acid delta(6)-desaturase activity,
long-chain fatty acid delta6-desaturase activity
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| Definition: |
Catalysis of the introduction of a cis double bond at carbon 6 of acyl-CoAs, introducing a new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid. Specific reactions include: (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O; and (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H+ = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. |