| Synonyms: |
activation of necroptosis,
activation of necroptosis by extracellular signals,
activation of necroptosis in response to extracellular signals,
activation of necroptosis of activated-T cells,
establishment of necroptosis,
establishment of necroptosis of activated-T cells,
extracellular signal-induced necroptosis,
induction of necroptosis,
induction of necroptosis by extracellular signals,
induction of necroptosis of activated-T cells,
necroptosis,
PARP-dependent cell death,
parthanatos,
programmed necrosis,
programmed necrotic cell death,
RIPK1-mediated regulated necrosis,
TNF-induced necroptosis
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| Definition: |
A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. |