Term Name:	mithramycin dehydrogenase (NADPH) activity
Synonyms:
Definition:	Catalysis of the reaction: mithramycin DK + NADPH + H+ = iso-mithramycin + NADP+. Note that iso-mithramycin (iso-MTM) is a C2-epimer of mithramycin. This intermediate appears to be biologically important because it is non-toxic, then exported out of the cell and finally spontaneously epimerized into the toxic mithramycin. This could represent a self-resistance mechanism against MTM toxicity.
Ontology:	GO: Molecular Function [GO:0102357]    QuickGO    AmiGO