Search Ontology:
ChEBI
GSK126
- Term ID
- CHEBI:124921
- Synonyms
-
- (S)-1-(sec-butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide
- 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indole-4-carboxamide
- GSK 126
- GSK 2816126
- GSK 2816126A
- GSK-126
- GSK-2816126
- GSK-2816126A
- GSK2816126
- GSK2816126A
- Definition
- A member of the class of methylindoles that is 1H-indole substituted by (2S)-butan-2-yl, methyl, N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]acetamide, and 6-(piperazin-1-yl)pyridin-3-yl groups at positions 1, 3, 4, and 6, respectively. It is a potent and highly selective inhibitor of EZH2 methyltransferase (IC50 = 9.9 nM).
- References
-
- cas:1346574-57-9
- lincs.smallmolecule:LSM-36365
- pdb-ccd:A9G
- pubmed:23051747
- pubmed:26898301
- pubmed:27868408
- pubmed:27926488
- pubmed:29070525
- pubmed:29545866
- pubmed:29654753
- pubmed:29904056
- pubmed:30737232
- pubmed:31471312
- pubmed:32298702
- pubmed:32529327
- pubmed:32606728
- pubmed:32772228
- pubmed:32805266
- pubmed:32906688
- pubmed:33085231
- pubmed:33467134
- pubmed:34149887
- pubmed:35091962
- pubmed:35864094
- pubmed:36087682
- pubmed:36469862
- pubmed:36652457
- pubmed:36734909
- pubmed:37010741
- pubmed:37558192
- pubmed:37644332
- pubmed:37989985
- pubmed:38009194
- pubmed:38362910
- pubmed:38446700
- pubmed:38530086
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from GSK126
Phenotype where environments contain GSK126
Phenotype modified by environments containing GSK126
Phenotype affecting GSK126
Human Disease Model