ceftolozane

Term ID

CHEBI:134719

Synonyms

• (6R,7R)-3-[(5-amino-4-{[(2-aminoethyl)carbamoyl]amino}-1-methyl-1H-pyrazol-2-ium-2-yl)methyl]-7-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• 7-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-[ (5-amino-4-{[(2-aminoethyl)carbamoyl]amino}-1-methyl-1H-pyrazol-2-ium-2-yl)methyl]-3,4-didehydrocepham-4-carboxylate
• ceftolozane
• ceftolozano
• ceftolozanum
• CXA-101

Definition

A fifth-generation cephalosporin antibiotic having (5-amino-4-{[(2-aminoethyl)carbamoyl]amino}-1-methyl-1H-pyrazol-2-ium-2-yl)methyl and [(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino side groups located at positions 3 and 7 respectively; developed for the treatment of infections with gram-negative bacteria that have become resistant to conventional antibiotics.

References

• cas:689293-68-3
• patent:US2017233408
• patent:WO2016028670
• pubmed:28689923
• pubmed:28923865
• pubmed:28980834
• pubmed:28993338
• pubmed:29017833
• pubmed:29167294
• pubmed:29493397
• pubmed:29517862
• pubmed:29521242
• reaxys:24720344
• wikipedia.en:Ceftolozane

Ontology

ChEBI  ( EBI )