Search Ontology:
ChEBI
6beta-hydroxycortisol
- Term ID
- CHEBI:139271
- Synonyms
-
- (6beta,11beta)-6,11,17,21-tetrahydroxypregn-4-ene-3,20-dione
- 6beta,11beta,17,21-tetrahydroxypregn-4-ene-3,20-dione
- 6beta-HO-cortisol
- 6beta-hydroxycortisol
- 6beta-OH-cortisol
- NSC 76163
- Definition
- A C21-steroid that is cortisol bearing an additional hydroxy substituent at the 6β-position. In humans, it is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo.
- References
-
- cas:53-35-0
- pubmed:14605790
- pubmed:16149517
- pubmed:16792464
- pubmed:17386716
- pubmed:19959402
- pubmed:20963880
- pubmed:21490593
- reaxys:2512454
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
Phenotype
Phenotype resulting from 6beta-hydroxycortisol
Phenotype where environments contain 6beta-hydroxycortisol
Phenotype modified by environments containing 6beta-hydroxycortisol
Phenotype affecting 6beta-hydroxycortisol
Human Disease Model