crenolanib

Term ID

CHEBI:145365

Synonyms

• 1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo-[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine
• 1-(2-{5-[(3-methyloxetan-3-yl)methoxy]-1H-1,3-benzodiazol-1-yl}quinolin-8-yl)piperidin-4-amine
• 1-(2-{5-[(3-methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine
• 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1-benzimidazolyl]-8-quinolyl]-4-piperidinamine
• 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine
• ARO 002
• ARO-002
• CP 868596
• CP-868,596
• CP-868596
• CP868569
• crenolanib
• crenolanibum

Definition

A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a 8-(4-aminopiperidin-1-yl)quinolin-2-yl group at position 1 and by a (3-methyloxetan-3-yl)methoxy group at position 5. It is an inhibitor of type III tyrosine kinases, PDGFRα/β and FLT3 (IC₅₀ of 11, 3.2, and 4 nM). Currently under clinical development for the treatment of acute myeloid leukemia.

References

• cas:670220-88-9
• drugbank:DB11832
• kegg.drug:D10102
• pdb-ccd:6T2
• pubmed:19738123
• pubmed:20959830
• pubmed:22745105
• pubmed:23644495
• pubmed:24046014
• pubmed:24132921
• pubmed:24227820
• pubmed:24263951
• pubmed:24623852
• pubmed:25328409
• pubmed:25597754
• pubmed:28433542
• pubmed:28943249
• pubmed:29137311
• pubmed:29191878
• pubmed:29312564
• pubmed:29472720
• pubmed:30651561
• pubmed:30942519
• pubmed:31235865
• pubmed:31309543
• wikipedia.en:Crenolanib

Ontology

ChEBI  ( EBI )