binimetinib

Term ID

CHEBI:145371

Synonyms

• 5-(4-bromo-2-fluoroanilino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
• 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-1,3-benzodiazole-6-carboxamide
• 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
• ARRY 162
• ARRY 438162
• ARRY-162
• ARRY-438162
• binimetinib
• binimetinibum
• MEK-162
• MEK162
• Mektovi
• N-(2-hydroxyethoxy)-4-fluoro-5-(2-fluoro-4-bromophenylamino)-1-methyl-1H-benzoimidazole-6-carboxamide
• NVP-MEK162

Definition

A member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-fluorophenyl)nitrilo, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor (IC₅₀= 12 nM). Approved by the FDA for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation in combination with encorafenib.

References

• cas:606143-89-9
• drugbank:DB11967
• kegg.drug:D10604
• lincs.smallmolecule:LSM-45640
• pmc:PMC6012544
• pubmed:23414587
• pubmed:27071922
• pubmed:28152546
• pubmed:28412197
• pubmed:28587477
• pubmed:28851243
• pubmed:29785570
• pubmed:29946554
• pubmed:30117021
• pubmed:30635233
• pubmed:30648436
• pubmed:30652516
• pubmed:30956763
• pubmed:31050693
• pubmed:31129802
• pubmed:31213500
• pubmed:31312030
• pubmed:31395751
• pubmed:31436845
• pubmed:31437754
• pubmed:31631932
• wikipedia.en:Binimetinib

Ontology

ChEBI  ( EBI )