CNDAC

Term ID

CHEBI:145435

Synonyms

• 1-(2-deoxy-2-cyano-beta-D-arabinofuranosyl)cytosine
• 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosyl-cytosine
• 2'-cyano-2'-deoxy-1-(beta-D-arabinofuranosyl)cytosine
• 4-amino-1-(2-cyano-2-deoxy-beta-D-arabinofuranosyl)pyrimidin-2(1H)-one
• DFP10917
• TAS 109
• TAS-109

Definition

A pyrimidine 2'-deoxyribonucleoside that is 2'-deoxycytidine having a cyano group in the 2'-position. It is the active metabolite of the anti-cancer drug, sapacitabine which is currently in clinical development for the treatment of hematologic malignancies and solid tumors.

References

• cas:135598-68-4
• drugbank:DB11667
• pubmed:20587622
• pubmed:22739266
• pubmed:23049558
• pubmed:27474148
• pubmed:28802254
• pubmed:29189915
• pubmed:31501277
• pubmed:8611048

Ontology

ChEBI  ( EBI )