GDC-0623

Term ID

CHEBI:167659

Synonyms

• 5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
• 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
• G 868
• G-868
• G868
• GDC 0623
• GDC0623
• RG 7421
• RG-7421

Definition

A member of the class of imidazopyridines that is imidazo[1,5-a]pyridine substituted by (2-fluoro-4-iodophenyl)amino and (2-hydroxyethoxy)aminoacyl groups at positions 5 and 6. It is a potent ATP non-competitive inhibitor of MEK1 (Ki = 0.13nM) and also has efficacy against both mutant BRAF and mutant KRAS. It is in clinical development for treatment of patients with locally advanced or metastatic solid tumors.

References

• cas:1168091-68-6
• chemspider:30687718
• drugbank:DB11982
• pdb-ccd:LCJ
• pubmed:23934108
• pubmed:25193232
• pubmed:26245900
• pubmed:26438627
• pubmed:27422710
• pubmed:31581174
• pubmed:32238059

Ontology

ChEBI  ( EBI )