nirmatrelvir

Term ID

CHEBI:170007

Synonyms

• (1R,2S,5S)-N-{(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
• nirmatrelvir
• nirmatrelvirum
• PF 07321332
• PF-07321332
• PF07321332

Definition

An azabicyclohexane that is (1R,5S)-3-azabicyclo[3.1.0]hexane substituted by {(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl}aminoacyl, 3-methyl-N-(trifluoroacetyl)-L-valinamide, methyl and methyl groups at positions 2S, 3, 6 and 6, respectively. It is the first orally administered inhibitor of SARS-CoV-2 main protease developed by Pfizer and used in combination with ritonavir for the treatment of COVID-19.

References

• cas:2628280-40-8
• drugbank:DB16691
• kegg.drug:D12244
• pmc:PMC9232762
• pmc:PMC9264725
• pubmed:34687004
• pubmed:35073029
• pubmed:35153195
• pubmed:35182772
• pubmed:35183067
• pubmed:35203821
• pubmed:35305258
• pubmed:35335157
• pubmed:35389231
• pubmed:35425393
• pubmed:35461811
• pubmed:35477935
• pubmed:35505633
• pubmed:35640480
• pubmed:35678736
• pubmed:35702394
• pubmed:35845944
• pubmed:36276807
• pubmed:36574296
• pubmed:36965419
• pubmed:37074087
• pubmed:37402789
• pubmed:37510996
• pubmed:37947496
• pubmed:38257765
• pubmed:38399271
• pubmed:38432955
• pubmed:38553607
• wikipedia.en:Nirmatrelvir

Ontology

ChEBI  ( EBI )