Search Ontology:
ChEBI
BAY11-7085
- Term ID
- CHEBI:176500
- Synonyms
-
- (2E)-3-(4-tert-butylbenzene-1-sulfonyl)prop-2-enenitrile
- (2E)-3-[(4-tert-butylphenyl)sulfonyl]prop-2-enenitrile
- (2E)-3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
- (E)-3-(4-t-butylphenylsulfonyl)-2-propenenitrile
- (E)-3-(4-tert-butylphenylsulfonyl)-2-propenenitrile
- Bay 11-7083
- Bay 11-7085
- Bay-11-7085
- BAY-117085
- Definition
- A sulfone that is benzene substituted by [(E)-2-cyanoethenyl]sulfonyl and tert-butyl groups at position 1 and 4, respectively. It is an irreversible inhibitor of IκB-α phosphorylation in cells (IC50 = 10 μM) and prevents the activation of NF-κB.
- References
-
- cas:196309-76-9
- chemspider:4510087
- lincs.smallmolecule:LSM-43815
- pubmed:14560113
- pubmed:15004016
- pubmed:16129475
- pubmed:16699956
- pubmed:16766531
- pubmed:16896168
- pubmed:17889719
- pubmed:22326395
- pubmed:23290051
- pubmed:25581261
- pubmed:26993765
- pubmed:28394395
- pubmed:29274359
- pubmed:30533198
- pubmed:30978702
- pubmed:32055188
- pubmed:32123585
- pubmed:34025434
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from BAY11-7085
Phenotype where environments contain BAY11-7085
Phenotype modified by environments containing BAY11-7085
Phenotype affecting BAY11-7085
Human Disease Model