itarnafloxin

Term ID

CHEBI:177533

Synonyms

• 5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-((R)-3-(pyrazin-2-yl)pyrrolidin-1-yl)-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide
• 5-fluoro-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-3-oxo-6-[3-(pyrazin-2-yl)pyrrolidin-1-yl]-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide
• CX 3543
• CX-3543
• CX3543
• itarnafloxin
• itarnafloxina
• itarnafloxine
• itarnafloxinum
• quarfloxacin
• quarfloxin

Definition

An organic heteropentacyclic compound that is 3H-benzo[b]pyrido[3,2,1-kl]phenoxazin-3-one substituted by 2-[(2S)-1-methylpyrrolidin-2-yl]ethanaminoacyl, fluoro, and 3-(pyrazin-2-yl)pyrrolidin-1-yl groups at positions 2, 5 and 6, respectively. It is a G-quadruplex interactive agent, previously in clinical trials for the treatment of carcinoid/neuroendocrine tumours (now discontinued).

References

• CAS:865311-47-3
• Chemspider:9810507
• DrugBank:DB06638
• KEGG:D08981
• PMCID:PMC6216854
• PMID:17344945
• PMID:19738048
• PMID:21113409
• PMID:24108400
• PMID:28211448
• PMID:28263991
• PMID:29311059
• PMID:30519593
• PMID:36195286
• PMID:37339720
• PMID:38041930
• PMID:39737570
• Patent:US20060029950

Ontology

ChEBI  ( EBI )