atogepant

Term ID

CHEBI:196955

Synonyms

• (3'S)-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide
• AGN-241689
• atogepant
• atogepantum
• MK-8031
• Qulipta

Definition

A secondary carboxamide resulting from the formal condensation of the carboxy group of (3'S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylic acid with the amino group of (3S,5S,6R)-3-amino-6-methyl-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-2-one. It is a selective oral, small-molecule antagonist of calcitonin gene-related peptide (CGRP) receptor that has been approved for the treatment of migraine.

References

• cas:1374248-81-3
• drugbank:DB16098
• kegg.drug:D11313
• pubmed:34407343
• pubmed:34813050
• pubmed:34964810
• pubmed:35085204
• pubmed:35093013
• pubmed:35230651
• pubmed:35319319
• pubmed:35332801
• pubmed:35358493
• pubmed:35469689
• pubmed:35493707
• pubmed:35675076
• pubmed:35705886
• pubmed:35983926
• pubmed:36153941
• pubmed:36226229
• pubmed:36396451
• pubmed:36552072
• pubmed:36602199
• pubmed:36620892
• pubmed:36651532
• pubmed:37038933
• pubmed:37210713
• pubmed:37278480
• pubmed:37424270
• pubmed:37516124
• pubmed:37516125
• pubmed:37564925
• pubmed:37630989
• pubmed:37638400
• pubmed:37650778
• pubmed:37656319
• wikipedia.en:Atogepant

Ontology

ChEBI  ( EBI )