daprodustat

Term ID

CHEBI:229223

Synonyms

daprodustat
daprodustatum
GSK 1278863
GSK-1278863
GSK1278863
Jesduvroq
N-[(1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidin-5-yl)carbonyl]glycine
{[(1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidin-5-yl)carbonyl]amino}acetic acid

Definition

A member of the class of barbiturates that is barbituric acid substituted by cyclohexyl groups at positions 1 and 3, and by a (carboxymethyl)aminocarbonyl group at position 5. It is an inhibitor of hypoxia-inducible factor prolyl hydroxylase developed by GlaxoSmithKline for the treatment of anaemia in patients with chronic kidney disease.

References

cas:960539-70-2
drugbank:DB11682
hmdb:HMDB0250863
kegg.drug:D10874
pubmed:25343825
pubmed:31640478
pubmed:32880805
pubmed:34739196
pubmed:34824467
pubmed:35191925
pubmed:35281917
pubmed:35355447
pubmed:35380500
pubmed:35534679
pubmed:35628849
pubmed:35639861
pubmed:35643373
pubmed:35983622
pubmed:36181513
pubmed:36195739
pubmed:36372403
pubmed:36565721
pubmed:36577110
pubmed:36577111
pubmed:36577112
pubmed:36739866
pubmed:36780413
pubmed:36868377
pubmed:37026612
pubmed:37116458
pubmed:37125459
pubmed:37156672
pubmed:37516063
pubmed:37637409
pubmed:37885335
pubmed:37926547
pubmed:38261926
pubmed:38412265
wikipedia.en:Daprodustat

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from daprodustat

Phenotype where environments contain daprodustat

Phenotype modified by environments containing daprodustat

Phenotype affecting daprodustat

Human Disease Model