orteronel

Term ID

CHEBI:231353

Synonyms

• (+)-orteronel
• (S)-orteronel
• 6-[(7S)-7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methylnaphthalene-2-carboxamide
• orteronel
• orteronelum
• TAK 700
• TAK-700
• TAK700

Definition

A member of the class of pyrroloimidazoles that is 6,7-dihydro-5H-pyrrolo[1,2-c]imidazole substituted by hydroxy and 6-(methylcarbamoyl)naphthalen-2-yl groups at position 7 (the 7S-stereoisomer). It is a non-steroidal 17,20-lyase inhibitor that suppresses androgen synthesis. It was previously in clinical development for the treatment of castration-resistant prostate cancer — trial now discontinued.

References

• cas:566939-85-3
• drugbank:DB12066
• kegg.drug:D10146
• pdb-ccd:7D6
• pmc:PMC4185570
• pmc:PMC4218005
• pubmed:21978946
• pubmed:22249003
• pubmed:22714983
• pubmed:22793031
• pubmed:23146910
• pubmed:23788266
• pubmed:23856460
• pubmed:24418642
• pubmed:24965748
• pubmed:25556680
• pubmed:25624429
• pubmed:26382777
• pubmed:26418412
• pubmed:27046420
• pubmed:27163496
• pubmed:27163497
• pubmed:27482286
• pubmed:28373265
• pubmed:28427507
• pubmed:31072872
• pubmed:32223238
• pubmed:34273352
• pubmed:34824002
• pubmed:35250590
• pubmed:35446628
• pubmed:37085425
• pubmed:37745904
• pubmed:38424319
• pubmed:38523017
• wikipedia.en:Orteronel

Ontology

ChEBI  ( EBI )