PF-06409577

Term ID

CHEBI:231658

Synonyms

• 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylic acid
• 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid
• PF 06409577
• PF06409577

Definition

A chloroindole that is 6-chloro-1H-indole substituted by carboxy and 4-(1-hydroxycyclobutyl)phenyl groups at positions 3 and 5, respectively. It is a potent and selective allosteric activator of AMPK and a potential treatment for diabetic nephropathy.

References

• cas:1467057-23-3
• hmdb:HMDB0244646
• pdb-ccd:6VT
• pubmed:27490827
• pubmed:28289077
• pubmed:29673898
• pubmed:29712653
• pubmed:29733844
• pubmed:30036059
• pubmed:30194276
• pubmed:32307703
• pubmed:34336655
• pubmed:35294578
• pubmed:35748097
• pubmed:36977628
• pubmed:38026185

Ontology

ChEBI  ( EBI )