WYE-28

Term ID

CHEBI:234113

Synonyms

• methyl 4-[6-[4-[[4-(hydroxymethyl)phenyl]carbamoylamino]phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
• methyl 4-{6-[4-({[4-(hydroxymethyl)phenyl]carbamoyl}amino)phenyl]-4-(morpholin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl}piperidine-1-carboxylate
• mTOR inhibitor WYE-28
• WYE 28
• WYE28

Definition

A pyrazolopyrimidine that is 1H-pyrazolo[3,4-d]pyrimidine substituted by 1-(methoxycarbonyl)piperidin-4-yl, morpholin-4-yl and 4-({[4-(hydroxymethyl)phenyl]carbamoyl}amino)phenyl groups at positions 1, 4, and 6, respectively. It is a potent inhibitor of mTOR (IC50 = 0.08 nM) and PI3Kalpha (IC50 = 6 nM).

References

• CAS:1062172-60-4
• PMID:19645448
• PMID:19916508
• PMID:39519056

Ontology

ChEBI  ( EBI )