fosinopril

Term ID

CHEBI:5163

Synonyms

• (2S,4S)-4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid
• (2S,4S)-4-cyclohexyl-1-{2-[(2-methyl-1-propionyloxy-propoxy)-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid
• (4S)-4-cyclohexyl-1-({[2-methyl-1-(propanoyloxy)propoxy](4-phenylbutyl)phosphoryl}acetyl)-L-proline
• (S)-4-Cyclohexyl-1-{2-[(2-methyl-1-propionyloxy-propoxy)-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid
• fosinopril

Definition

A phosphinate ester-containing N-acyl derivative of (4S)-cyclohexyl-L-proline. It is used for the treatment of hypertension and heart failure. A pro-drug, it is hydrolysed in vivo to the corresponding phosphininc acid, fosinoprilat, which is the active metabolite.

References

• beilstein:8176492
• cas:98048-97-6
• drugbank:DB00492
• kegg.compound:C07016
• kegg.drug:D07992
• lincs.smallmolecule:LSM-6485
• patent:CN101367839
• patent:EP2264039
• patent:US2010297711
• patent:US4337201
• pubmed:11937741
• pubmed:18209565
• pubmed:22729889
• pubmed:8285178
• pubmed:9195116

Ontology

ChEBI  ( EBI )

Resources

CTD