bivalirudin

Term ID

CHEBI:59173

Synonyms

• (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-4-amino-2-[[2-[[2-[[2-[[2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2R)-2-amino-3-cyclohexylpropanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]pyrrolidi
• bivalirudin
• bivalirudina
• bivalirudine
• bivalirudinum
• D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl-L-leucine

Definition

A synthetic peptide of 20 amino acids, comprising D-Phe, Pro, Arg, Pro, Gly, Gly, Gly, Gly, Asn, Gly, Asp, Phe, Glu, Glu, Ile, Pro, Glu, Glu, Tyr, and Leu in sequence. A congener of hirudin (a naturally occurring drug found in the saliva of the medicinal leech), it a specific and reversible inhibitor of thrombin, and is used as an anticoagulant.

References

• beilstein:12004535
• cas:128270-60-0
• drugbank:DB00006
• drugcentral:385
• patent:WO9102750
• pubmed:28844201
• pubmed:29086730
• pubmed:29276283
• pubmed:29342377
• pubmed:29345439
• pubmed:29345440
• pubmed:29345441
• pubmed:29345444
• pubmed:29350380
• pubmed:29377655
• pubmed:29461391
• pubmed:29477790
• pubmed:29544607
• pubmed:29563377
• pubmed:29600024

Ontology

ChEBI  ( EBI )

Resources

CTD