pemetrexed

Term ID

CHEBI:63616

Synonyms

• N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid
• pemetrexed

Definition

An N-acylglutamic acid in which the N-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).

References

• cas:137281-23-3
• drugbank:DB00642
• kegg.drug:D07472
• lincs.smallmolecule:LSM-6353
• patent:EP432677
• patent:US5344932
• pubmed:21129871
• pubmed:21831719
• pubmed:21900836
• pubmed:21937141
• pubmed:22021325
• pubmed:22116317
• pubmed:22124474
• pubmed:22134068
• pubmed:22201521
• pubmed:22223137
• pubmed:22237209
• pubmed:22240216
• pubmed:22243773
• pubmed:22244076
• pubmed:22258853
• reaxys:9097855
• wikipedia.en:Pemetrexed

Ontology

ChEBI  ( EBI )