iloprost

Term ID

CHEBI:63916

Synonyms

• (16R,S)-methyl-18,18,19,19-tetradehydro-6a-carbaprostaglandin I2
• (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid
• iloprost
• iloprostum

Definition

A carbobicyclic compound that is prostaglandin I₂ in which the endocyclic oxygen is replaced by a methylene group and in which the (1E,3S)-3-hydroxyoct-1-en-1-yl side chain is replaced by a (3R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl group. A synthetic analogue of prostacyclin, it is used as the trometamol salt (generally by intravenous infusion) for the treatment of peripheral vascular disease and pulmonary hypertension.

References

• cas:78919-13-8
• drugbank:DB01088
• drugcentral:1422
• kegg.drug:D02721
• patent:DE2845770
• patent:US4692464
• pubmed:14719835
• pubmed:15232651
• pubmed:15241524
• pubmed:19436672
• reaxys:4329060
• wikipedia.en:Iloprost

Ontology

ChEBI  ( EBI )