celastrol

Term ID

CHEBI:63959

Synonyms

• (2R,4aS,6aS,12bR,14aS,14bR)-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-2-picenecarboxylic acid
• (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
• 3-hydroxy-9beta,13alpha-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
• D:A-Friedo-24-noroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-2-oxo-, (20alpha)-
• Tripterine

Definition

A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-α-induced NFκB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 μM).

References

• cas:34157-83-0
• hmdb:HMDB0002385
• patent:KR20100097843
• patent:US2011263693
• pubmed:11809076
• pubmed:15593077
• pubmed:20934245
• pubmed:20954803
• pubmed:21134410
• pubmed:21414301
• pubmed:21425580
• pubmed:21466843
• pubmed:21569548
• pubmed:21666907
• pubmed:21850367
• pubmed:21865725
• pubmed:21866552
• pubmed:22087583
• pubmed:22206928
• pubmed:22334592
• reaxys:2194425

Ontology

ChEBI  ( EBI )