Search Ontology:
ChEBI
antroquinonol
- Term ID
- CHEBI:65415
- Synonyms
-
- (4R,5R,6R)-4-hydroxy-2,3-dimethoxy-6-methyl-5-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]cyclohex-2-en-1-one
- Definition
- An enone that is cyclohex-2-en-1-one substituted by a hydroxy group at position 4, methoxy groups at positions 2 and 3, a methyl group at position 6 and a (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl group at position 5 (the 4R,5R,6R stereoisomer). It is isolated from the solid-state fermented mycelium of the fungus Antrodia camphorata and has been found to exhibit potent cytotoxicity against a number of human cancer cell lines. However, a synthesis-enabled biological re-examination published in 2016, revealed minimal in vitro and in vivo antitumour activity in preclinical models.
- References
-
- pubmed:17932820
- pubmed:19723512
- pubmed:21540101
- pubmed:21840189
- pubmed:21905011
- pubmed:25679542
- pubmed:25875221
- pubmed:26039178
- pubmed:27163023
- pubmed:27997180
- reaxys:11257757
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from antroquinonol
Phenotype where environments contain antroquinonol
Phenotype modified by environments containing antroquinonol
Phenotype affecting antroquinonol
Human Disease Model