doxapram

Term ID

CHEBI:681848

Synonyms

• (+-)-doxapram
• 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone
• 1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one
• doxapram

Definition

A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.

References

• cas:309-29-5
• drugbank:DB00561
• drugcentral:953
• kegg.drug:D07873
• lincs.smallmolecule:LSM-5058
• patent:BE613734
• patent:US3192206
• pubmed:19663568
• pubmed:20140700
• pubmed:25819170
• pubmed:26896538
• pubmed:4122029
• pubmed:4126096
• pubmed:527638
• reaxys:628691
• vsdb:1819
• wikipedia.en:Doxapram

Ontology

ChEBI  ( EBI )

Resources

CTD