tipiracil

Term ID

CHEBI:90879

Synonyms

5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4(1H,3H)-dione
tipiracil

Definition

A member of the class of pyrimidones that is uracil substituted by chloro and (2-iminopyrrolidin-1-yl)methyl groups at positions 5 and 6 respectively. Used (as the hydrochloride salt) in combination with trifluridine, a nucleoside metabolic inhibitor, for treatment of advanced/relapsed unresectable colorectal cancer.

References

cas:183204-74-2
drugcentral:4893
pubmed:24562648
pubmed:25230742
pubmed:25750295
pubmed:25812794
pubmed:25900515
pubmed:25901475
pubmed:25970050
pubmed:26084259
pubmed:26163340
pubmed:26197742
pubmed:26254349
pubmed:26370544
pubmed:26428513
pubmed:26509228
pubmed:26535019
pubmed:26609205
pubmed:26616466
pubmed:26677869
pubmed:26722024
pubmed:26723516
pubmed:26730280
reaxys:9272220
wikipedia.en:Tipiracil

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from tipiracil

Phenotype where environments contain tipiracil

Phenotype modified by environments containing tipiracil

Phenotype affecting tipiracil

Human Disease Model