lumacaftor

Term ID

CHEBI:90951

Synonyms

• 3-(6-{[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-carbonyl]amino}-3-methylpyridin-2-yl)benzoic acid
• lumacaftor
• VRT 826809
• VRT-826809
• VX 809
• VX-809

Definition

An aromatic amide obtained by formal condensation of the carboxy group of 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid with the aromatic amino group of 3-(6-amino-3-methylpyridin-2-yl)benzoic acid. Used for the treatment of cystic fibrosis.

References

• cas:936727-05-8
• drugcentral:5010
• kegg.drug:D10134
• pubmed:24771136
• pubmed:24973281
• pubmed:25981758
• pubmed:26071414
• pubmed:26416827
• pubmed:26417173
• pubmed:26492939
• pubmed:26506855
• pubmed:26510034
• pubmed:26510035
• pubmed:26567541
• pubmed:26581802
• pubmed:26718821
• reaxys:12892616
• wikipedia.en:Lumacaftor

Ontology

ChEBI  ( EBI )