Search Ontology:
ChEBI
YK-4-279
- Term ID
- CHEBI:94301
- Synonyms
-
- 4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one
- 4,7-dichloro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one
- 4,7-dichloro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1H-indol-2-one
- YK 4-279
- YK 4279
- YK4279
- Definition
- A member of the class of indolones that is 1,3-dihydro-2H-indol-2-one substituted by hydroxy, 2-(4-methoxyphenyl)-2-oxoethyl, chloro, and chloro groups at positions 3, 3, 4, and 7, respectively. It blocks RNA helicase A binding to EWS-FLI1, induces apoptosis, and exhibits antineoplastic activity.
- References
-
- cas:1037184-44-3
- drugbank:DB17428
- pmc:PMC9443279
- pubmed:19584866
- pubmed:21559405
- pubmed:22383402
- pubmed:25479232
- pubmed:25964201
- pubmed:26462019
- pubmed:28553168
- pubmed:28602975
- pubmed:28668826
- pubmed:28974650
- pubmed:29212266
- pubmed:31182435
- pubmed:32016454
- pubmed:33020273
- pubmed:33526511
- pubmed:34221969
- pubmed:35008307
- pubmed:38386842
- pubmed:38579174
- pubmed:38584823
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from YK-4-279
Phenotype where environments contain YK-4-279
Phenotype modified by environments containing YK-4-279
Phenotype affecting YK-4-279
Human Disease Model