Search Ontology:
ChEBI
LY404039
- Term ID
- CHEBI:94640
- Synonyms
-
- (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid
- (1R,4S,5S,6S)-4-amino-2,2-dioxo-2lambda(6)-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
- (1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
- LY 404039
- LY-404,039
- LY-404039
- LY404039
- pomaglumetad
- Definition
- An organic heterobicyclic compound that is (1S,5R)-2-thiabicyclo[3.1.0]hexane carrying oxo, oxo, amino, carboxy, and carboxy groups at positions 2, 2, 4S, 4S, and 6S, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 mGluR3 (Ki = 149 nM and 92 nM, respectively) and exhibits antipsychotic and anxiolytic efficacy in animal models.
- References
-
- cas:635318-11-5
- chemspider:8010312
- kegg.compound:C21577
- lincs.smallmolecule:LSM-5605
- pubmed:16678921
- pubmed:17204749
- pubmed:17384937
- pubmed:18424625
- pubmed:19006848
- pubmed:20571979
- pubmed:21847569
- pubmed:22884896
- pubmed:23694720
- pubmed:24486391
- pubmed:25382826
- pubmed:25755052
- pubmed:31308026
- pubmed:32403118
- wikipedia.en:Pomaglumetad
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from LY404039
Phenotype where environments contain LY404039
Phenotype modified by environments containing LY404039
Phenotype affecting LY404039
Human Disease Model