pimasertib

Term ID

CHEBI:94793

Synonyms

AS 703026
AS-703026
AS703026
MSC 1936369B
MSC-1236369B
MSC1936369B
N-[(2S)-2,3-dihydroxypropyl]-3-(2-fluoro-4-iodoanilino)-4-pyridinecarboxamide
N-[(2S)-2,3-dihydroxypropyl]-3-(2-fluoro-4-iodoanilino)pyridine-4-carboxamide
pimasertib
pimasertibum
SAR 245509
SAR-245509
SAR245509

Definition

A secondary carboxamide resulting from the formal condensation of the carboxy group of 3-(2-fluoro-4-iodoanilino)pyridine-4-carboxylic acid with the amino group of (2S)-3-aminopropane-1,2-diol. It is a potent inhibitor of the mitogen-activated protein kinases MEK1 and MEK2 with potential antineoplastic activity.

References

cas:1236699-92-5
drugbank:DB14904
kegg.drug:D10426
lincs.smallmolecule:LSM-5946
pdb-ccd:QOA
pubmed:20331454
pubmed:24051957
pubmed:25989270
pubmed:26033306
pubmed:26381508
pubmed:26444523
pubmed:26640591
pubmed:26657199
pubmed:26924269
pubmed:26961147
pubmed:27179113
pubmed:27179114
pubmed:27483391
pubmed:27934635
pubmed:28151716
pubmed:28194539
pubmed:28289865
pubmed:29338133
pubmed:29488172
pubmed:29756206
pubmed:30425349
pubmed:30585255
pubmed:30848427
pubmed:31482223
pubmed:31586300
pubmed:31870556
pubmed:32610581
pubmed:33170484
pubmed:33211315
pubmed:34470822
pubmed:37097377

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from pimasertib

Phenotype where environments contain pimasertib

Phenotype modified by environments containing pimasertib

Phenotype affecting pimasertib

Human Disease Model