acyl-CoA 6-desaturase activity

Term ID

GO:0016213

Synonyms

• delta(6)-acyl CoA desaturase activity
• delta(6)-desaturase activity
• delta(6)-fatty acyl-CoA desaturase activity
• delta6-acyl CoA desaturase activity
• delta6-desaturase activity
• delta6-fatty acyl-CoA desaturase activity
• fatty acid 6-desaturase activity
• fatty acid delta(6)-desaturase activity
• fatty acid delta6-desaturase activity
• linoleate desaturase activity
• linoleic acid desaturase activity
• linoleic desaturase activity
• linoleoyl CoA desaturase activity
• linoleoyl-CoA desaturase activity
• linoleoyl-coenzyme A desaturase activity
• long-chain fatty acid delta(6)-desaturase activity
• long-chain fatty acid delta6-desaturase activity

Definition

Catalysis of the introduction of a cis double bond at carbon 6 of acyl-CoAs, introducing a new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid. Specific reactions include: (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O; and (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H+ = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. (3)

References

• EC:1.14.19.3
• MetaCyc:1.14.19.3-RXN
• Reactome:R-HSA-2046084
• Reactome:R-HSA-2046096
• Reactome:R-HSA-2046097
• Reactome:R-HSA-2046099

Ontology

GO: Molecular Function    QuickGO    AmiGO