keratan sulfate proteoglycan biosynthetic process

Term ID

GO:0018146

Synonyms

• keratan sulfate anabolism
• keratan sulfate biosynthesis
• keratan sulfate formation
• keratan sulfate synthesis
• keratan sulphate biosynthesis
• keratan sulphate biosynthetic process

Definition

The chemical reactions and pathways resulting in the formation of keratan sulfate proteoglycans, which consist of a core protein linked to a keratan sulfate glycosaminoglycan. The keratan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-beta-(1,3)-galactose, both of which can be sulfated. Keratan sulfate chains can be covalently linked either to an asparagine residue (N-linked) of the core protein via a high mannose oligasacccharide linker or to serine/threonine residues (O-linked) of the core protein via a core 2 type-linker. 29340594

References

• Reactome:R-HSA-2022854

Ontology

GO: Biological Process    QuickGO    AmiGO