Search Ontology:
GO: Molecular Function

mithramycin dehydrogenase (NADPH) activity

Term ID
GO:0102357
Synonyms
Definition
Catalysis of the reaction: mithramycin DK + NADPH + H+ = iso-mithramycin + NADP+. Note that iso-mithramycin (iso-MTM) is a C2-epimer of mithramycin. This intermediate appears to be biologically important because it is non-toxic, then exported out of the cell and finally spontaneously epimerized into the toxic mithramycin. This could represent a self-resistance mechanism against MTM toxicity. 31702856
References
  • MetaCyc:RXN-13385
Ontology
GO: Molecular Function    QuickGO    AmiGO
Relationships
is a type of
Phenotype
Phenotype caused by Genes
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