ZFIN All Figures, O'Brown <i>et al.</i>, 2023

Fig. 1

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Genes:	EGFP mCherry
Fish:	s896Tg sj3Tg spock1^hm41/+; s896Tg spock1^hm41/hm41; s896Tg spock1^hm43/+; spock1^hm41/+; s896Tg spock1^hm43/hm43; sj3Tg
Anatomical Terms:	brain brain vasculature blood vessel endothelial cell
Stage Range:	Protruding-mouth to Days 7-13

Expression / Labeling details

PHENOTYPE:

Fish:	spock1^hm41/+; s896Tg spock1^hm41/hm41; s896Tg spock1^hm43/+; spock1^hm41/+; s896Tg spock1^hm43/hm43; sj3Tg
Observed In:	brain brain vasculature establishment of blood-brain barrier
Stage Range:	Protruding-mouth to Adult

Phenotype details

Fig. 2

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Genes:	Citrine elavl3 mCherry spock1
Fish:	s896Tg spock1^hm44Tg; hm30Tg
Anatomical Terms:	brain brain neuron brain vasculature blood vessel endothelial cell retina spinal cord whole organism
Stage:	Day 5

Expression / Labeling details

Fig. 3

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:

Fish:	spock1^hm41/hm41
Observed In:	blood vessel endothelial cell cytoplasmic vesicle brain vasculature blood vessel endothelial cell pericyte basement membrane
Stage:	Days 7-13

Phenotype details

Fig. 4

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Gene:	mCherry
Antibodies:	Ab4-col4 Ab4-fn
Fish:	s896Tg spock1^hm41/hm41; s896Tg
Anatomical Terms:	brain vasculature basement membrane brain vasculature blood vessel endothelial cell
Stage:	Day 5

Expression / Labeling details

PHENOTYPE:

Fish:	spock1^hm41/hm41; s896Tg
Observed In:	brain vasculature basement membrane brain vasculature regulation of extracellular matrix organization forebrain metallopeptidase activity midbrain metallopeptidase activity
Stage:	Day 5

Phenotype details

Fig. 6

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Genes:	foxc1b mcamb mCherry notch3
Fish:	s896Tg spock1^hm41/hm41; s896Tg
Anatomical Terms:	hindbrain blood vessel endothelial cell hindbrain pericyte midbrain blood vessel endothelial cell midbrain pericyte
Stage:	Day 5

Expression / Labeling details

PHENOTYPE:

Fish:	spock1^hm41/hm41; s896Tg
Observed In:	midbrain blood vessel endothelial cell midbrain pericyte
Stage:	Day 5

Phenotype details

Fig. 7

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Cell, 58(17), O'Brown, N.M., Patel, N.B., Hartmann, U., Klein, A.M., Gu, C., Megason, S.G., The secreted neuronal signal spock1 promotes blood-brain barrier development, 1534-1547.e6, Copyright (2023) with permission from Elsevier. Full text @ Dev. Cell

O'Brown et al., 2023 ZDB-PUB-230713-39 PMID:37437574

The secreted neuronal signal spock1 promotes blood-brain barrier development

O'Brown et al., 2023

ZDB-PUB-230713-39
PMID:37437574