bmp4

ID

ZDB-GENE-980528-2059

Name

bone morphogenetic protein 4

Symbol

bmp4 Nomenclature History

Previous Names

bmp-4
zbmp-4
etID309887.17 (1)
zgc:100779

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable cytokine activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; determination of bilateral symmetry; and embryonic organ development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; fin; head; mesoderm; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and syndromic microphthalmia 6. Orthologous to human BMP4 (bone morphogenetic protein 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

324 figures from 249 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu728 (27 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 21 figures from 10 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bmp4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
orofacial cleft 11	Alliance	Orofacial cleft 11	600625
syndromic microphthalmia 6	Alliance	Microphthalmia, syndromic 6	607932

Associated With bmp4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017948	Transforming growth factor beta, conserved site
Domain	IPR001111	TGF-beta, propeptide
Domain	IPR001839	Transforming growth factor-beta, C-terminal
Domain	IPR047833	Bone morphogenetic protein 4, TGF-beta-like domain
Family	IPR015615	Transforming growth factor-beta-related
Homologous_superfamily	IPR029034	Cystine-knot cytokine