FIGURE

Fig. 4

ID

ZDB-FIG-101119-22

Publication

Cao et al., 2009 - Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models

Other Figures

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Fig. 4

Depletion of hdac1 can suppress the phenotypes of pkd2 mutants. (A and B) Phenotypes of hdac1/hi1618 mutants on 2 dpf in side views. (A) shows a wild-type (WT) sibling, while (B) shows a mutant embryo (hi1618). (C–E) Injection of hdac1 morpholino can suppress body curvature of pkd2/hi4166 mutants on 2 pdf. (C) shows mutant embryos injected with the five base-pair mismatch control oligo. (D) shows mutant embryos injected with the hdac1 morpholino. (E) shows average curvature angle in embryos injected with control or hdac1 morpholino. n = 5, *, P < 0.05. (F–H) Injection of hdac1 morpholino can suppress kidney cyst formation in pkd2 morphants (pkd2mo) on 3 pdf. 4166: embryos from pkd2/hi4166 heterozygous cross; ctrolMO: embryos injected with control morpholino. HDAC1 MO: embryos injected with hdac1 morpholino.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hdac1^{hi1618Tg/hi1618Tg} (AB/TU) pkd2^{hi4166Tg/hi4166Tg} (AB/TU) pkd2^{hi4166Tg/hi4166Tg} + MO1-hdac1 (AB/TU)
Knockdown Reagent:	MO1-hdac1
Observed In:	pericardium whole organism
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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