FIGURE

Fig. 4

ID

ZDB-FIG-120209-10

Publication

Hall et al., 2012 - Infection-Responsive Expansion of the Hematopoietic Stem and Progenitor Cell Compartment in Zebrafish Is Dependent upon Inducible Nitric Oxide

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Fig. 4

cebpβ Is Expressed within HSPCs in Response to Infection and Is Required for Demand-Driven Granulopoiesis (A) Expression of cebpβ within the AGM of infected larvae, compared with PBS controls at 12 hpi and 2 dpi. (B) Dual WMISH of cebpβ and runx1 within the AGM of infected larvae at 12 hpi. (C) Dual WMISH of cebpβ and lyz within the AGM of infected larvae at 2 dpi. (D) Control MO- and C/ebpβ MO-injected Tg(lyz:EGFP)/Tg(gata1:DsRED) larvae following infection, compared with PBS controls at 2 dpi. Numbers represent frequency of embryos or larvae with displayed phenotype. Scale bar, 100 μm in (D). All views, anterior to left. Abbreviations: DA, dorsal aorta; PCV, posterior cardinal vein. See also Figure S4.

Expression Data

Genes:	cebpb EGFP lyz runx1
Fish:	WT nz117Tg; sd2Tg nz117Tg; sd2Tg + MO1-cebpb
Condition:	bacterial treatment: Salmonella enterica subsp. enterica serovar Typhimurium
Knockdown Reagent:	MO1-cebpb
Anatomical Terms:	neutrophil ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic stem cell ventral wall of dorsal aorta neutrophil
Stage Range:	Pec-fin to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nz117Tg; sd2Tg
Condition:	bacterial treatment: Salmonella enterica subsp. enterica serovar Typhimurium
Observed In:	neutrophil
Stage:	Day 4

Phenotype Detail

Acknowledgments

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