FIGURE

Figure 2

ID

ZDB-FIG-210801-38

Publication

Ogura et al., 2021 - Loss of αklotho causes reduced motor ability and short lifespan in zebrafish

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Figure 2

Zebrafish kl mutants become thinner and undergo premature death. (a–d) The kl^+/+ female (a), kl^+/+ male (b), kl^−/− female (c) and kl^−/− male (d) zebrafish at 4 mpf. The kl^−/− fish showed no morphological defects at this stage. (e–l) Lateral and dorsal views of head in kl^+/+ female (e,i), kl^+/+ male (f,j), kl^−/− female (g,k) and kl^−/− male (h,l) at 5 mpf. Note that the eyeball is protruding to the outside in the kl^−/− female. (m–p) The kl^+/+ female (m), kl^+/+ male (n), kl^−/− female (o) and kl^−/− male (p) zebrafish at 6 mpf. The kl^−/− fish became skinny. (q) The kl^+/+ fish (n = 32) survived over 9 mpf. All of the kl^−/− fish (n = 28) underwent premature death before 9 mpf.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kl^{sa18644/sa18644}
Observed In:	female organism eye whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

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